Cell Disruptor

Effective Cell Disruption with Bullet Blender

Cell disruption involves breaking open cells to release intracellular components, such as DNA, RNA, protein molecules, organelles, or other particles of interest. When lysing tissue or plant cells, it is ideal to recover the highest viable yield of these molecules. The Bullet Blender bead mill homogenizer uses lysis beads to obtain a wide range of intracellular components while also maximizing the yield. 

The bead mill homogenizer prepares up to 24 samples in just minutes. It uses patented striking technology to thoroughly lyse samples for downstream applications. All of the samples are automatically homogenized in the same manner, with high yields, so there is very little variation from sample to sample. See the Protocols page for preparation times and speeds.

No Cross Contamination

No part of the Bullet Blender ever touches the cells – the sample tubes are kept closed during homogenization. There are no probes to clean between samples.

Samples Stay Cool

The Bullet Blenders’ innovative and elegant design provides convective cooling of the samples, so they do not heat up more than several degrees. In fact, our Gold+ models hold the sample temperature at around 4ºC.

Easy and Convenient to Use

Just place beads and buffer along with your cells in standard tubes, load tubes directly in the Bullet Blender, select time and speed, and press start.

Bullet Blender Storm Pro Bead Mill Homoenizer. Has a powerful motor to effectively disrupt cells from whole tissue.
Bullet Blender 5E Gold+ has an integrated cooling system that helps to maintains sample temperatures at 4°C.

DNA From Plant and Small Organism Samples Extracted Using the Next Advance Bullet Blender and PrecisionPak. DNA from 30mg of strawberry and rose leaves and DNA from 50 mg of small organism samples was extracted and run on a 1% Agarose gel. M – 1 kb ladder. 

RNA from Mouse Liver Samples Extracted Using Next Advance Bullet Blender and PrecisionPak. RNA from 50 mg of mouse liver was homogenized using the Bullet Blender Storm Pro. RNA was extracted from the homogenate.

Let Us Design Your Protocol for You!

We’ll give you a pre-optimized protocol that we GUARANTEE will homogenize your samples consistently and reproducibly.

Three tubes with unhomogenized mouse femur.
Before
Three tubes with homogenized mouse femur.
After

If you purchase a Bullet Blender, you’ll get a 30-day money-back guarantee!

Try our protocol with no risk. We’re certain that you’ll love the Bullet Blender.