Drosophila Homogenizer & Homogenization Protocol

Ideal for Drosophila Tissue Homogenization

Do you spend lots of time and effort homogenizing drosophila tissue samples? The Bullet Blender® tissue homogenizer delivers high quality and superior yields. No other homogenizer comes close to delivering the Bullet Blender’s winning combination of top-quality performance and budget-friendly affordability. See below for a drosophila tissue homogenization protocol.

Save Time, Effort and Get Superior Results with

The Bullet Blender Homogenizer

Consistent and High Yield Results

Run up to 24 samples at the same time under microprocessor-controlled conditions, ensuring experimental reproducibility and high yield. Process samples from 10mg or less up to 3.5g.

No Cross Contamination

No part of the Bullet Blender ever touches the tissue – the sample tubes are kept closed during homogenization. There are no probes to clean between samples.

Samples Stay Cool

The Bullet Blenders’ innovative and elegant design provides convective cooling of the samples, so they do not heat up more than several degrees. In fact, our Gold+ models hold the sample temperature to about 4ºC.

Easy and Convenient to Use

Just place beads and buffer along with your tissue sample in standard tubes, load tubes directly in the Bullet Blender, select time and speed, and press start.

Risk Free Purchase

Thousands of peer-reviewed journal articles attest to the consistency and quality of the Bullet Blender homogenizer. We offer a 2 year warranty, extendable to 4 years, because our Bullet Blenders are reliable and last for many years.  

Drosophila Tissue Homogenization Protocol

Sample size

See the Protocol

microcentrifuge tube model (up to 300 mg) Small drosophila/fruit fly samples
5mL tube model (100mg - 1g) Medium drosophila/fruit fly samples

What Else Can You Homogenize? Tough or Soft, No Problem! 

The Bullet Blender can process a wide range of samples including organ tissue, cell culture, plant tissue, and small organisms. You can homogenize samples as tough as mouse femur or for gentle applications such as tissue dissociation or organelle isolation.

the Bullet Blender high-throughput tissue homogenizer
Drosophila before

 Whole drosophila (floating over beads in upper photo) are completely homogenized into the buffer (darker in lower photo).

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    Bullet Blender Models

    Select Publications using the Bullet Blender to Homogenize Drosophila Tissue

    Herter, E. K., Stauch, M., Gallant, M., Wolf, E., Raabe, T., & Gallant, P. (2015). snoRNAs are a novel class of biologically relevant Myc targets. BMC Biology, 13(1). https://doi.org/10.1186/s12915-015-0132-6
    Heisig, M., Abraham, N. M., Liu, L., Neelakanta, G., Mattessich, S., Sultana, H., Shang, Z., Ansari, J. M., Killiam, C., Walker, W., Cooley, L., Flavell, R. A., Agaisse, H., & Fikrig, E. (2014). Antivirulence Properties of an Antifreeze Protein. Cell Reports, 9(2), 417–424. https://doi.org/10.1016/j.celrep.2014.09.034
    Kim, Y. H., Kwon, D. H., Ahn, H. M., Koh, Y. H., & Lee, S. H. (2014). Induction of soluble AChE expression via alternative splicing by chemical stress in Drosophila melanogaster. Insect Biochemistry and Molecular Biology, 48, 75–82. https://doi.org/10.1016/j.ibmb.2014.03.001
    Hu, Y., Sopko, R., Foos, M., Kelley, C., Flockhart, I., Ammeux, N., Wang, X., Perkins, L., Perrimon, N., & Mohr, S. E. (2013). FlyPrimerBank: An Online Database for Drosophila melanogaster Gene Expression Analysis and Knockdown Evaluation of RNAi Reagents. G3: Genes|Genomes|Genetics, 3(9), 1607–1616. https://doi.org/10.1534/g3.113.007021
    Marshall, K. E. (2013). The sub-lethal effects of repeated cold exposure in insects. University of Western Ontario.
    Koles, K., Nunnari, J., Korkut, C., Barria, R., Brewer, C., Li, Y., Leszyk, J., Zhang, B., & Budnik, V. (2012). Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons. Journal of Biological Chemistry, 287(20), 16820–16834. https://doi.org/10.1074/jbc.M112.342667
    Marshall, K. E., & Sinclair, B. J. (2010). Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. Proceedings of the Royal Society B: Biological Sciences, 277(1683), 963–969. https://doi.org/10.1098/rspb.2009.1807
    Bazinet, A. L., Marshall, K. E., MacMillan, H. A., Williams, C. M., & Sinclair, B. J. (2010). Rapid changes in desiccation resistance in Drosophila melanogaster are facilitated by changes in cuticular permeability. Journal of Insect Physiology, 56(12), 2006–2012. https://doi.org/10.1016/j.jinsphys.2010.09.002

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