Nematode (C. elegans) Homogenizer & Homogenization Protocols

Ideal for C. elegans Tissue Homogenization

Do you spend lots of time and effort homogenizing C. elegans tissue samples? The Bullet Blender® tissue homogenizer delivers high quality and superior yields. No other homogenizer comes close to delivering the Bullet Blender’s winning combination of top-quality performance and budget-friendly affordability. See below for a C. elegans tissue homogenization protocol.

Save Time, Effort and Get Superior Results with

The Bullet Blender Homogenizer

Consistent and High Yield Results

Run up to 24 samples at the same time under microprocessor-controlled conditions, ensuring experimental reproducibility and high yield. Process samples from 10mg or less up to 3.5g.

No Cross Contamination

No part of the Bullet Blender ever touches the tissue – the sample tubes are kept closed during homogenization. There are no probes to clean between samples.

Samples Stay Cool

The Bullet Blenders’ innovative and elegant design provides convective cooling of the samples, so they do not heat up more than several degrees. In fact, our Gold+ models hold the sample temperature to about 4ºC.

Easy and Convenient to Use

Just place beads and buffer along with your tissue sample in standard tubes, load tubes directly in the Bullet Blender, select time and speed, and press start.

Risk Free Purchase

Thousands of peer-reviewed journal articles attest to the consistency and quality of the Bullet Blender homogenizer. We offer a 2 year warranty, extendable to 4 years, because our Bullet Blenders are reliable and last for many years.  

C. elegans Tissue Homogenization Protocol

Sample size

See the Protocol

microcentrifuge tube model (up to 300 mg) Small C.elegans samples
5mL tube model (100mg - 1g) Medium C.elegans samples

What Else Can You Homogenize? Tough or Soft, No Problem! 

The Bullet Blender can process a wide range of samples including organ tissue, cell culture, plant tissue, and small organisms. You can homogenize samples as tough as mouse femur or for gentle applications such as tissue dissociation or organelle isolation.

the Bullet Blender high-throughput tissue homogenizer

C. elegans tissue pieces (on beads in upper photo) are completely homogenized into the buffer (slightly darker in lower photo). 

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    Bullet Blender Models

    Select Publications using the Bullet Blender to Homogenize C. elegans

    Romero-Afrima, L., Zelmanovich, V., Abergel, Z., Zuckerman, B., Shaked, M., Abergel, R., Livshits, L., Smith, Y., & Gross, E. (2020). Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans. Redox Biology, 28, 101359. https://doi.org/10.1016/j.redox.2019.101359
    Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., & Cravatt, B. F. (2019). Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature Chemical Biology, 15(5), 453–462. https://doi.org/10.1038/s41589-019-0243-4
    Gooyit, M., Tricoche, N., Lustigman, S., & Janda, K. D. (2014). Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting. Journal of Medicinal Chemistry, 57(13), 5792–5799. https://doi.org/10.1021/jm5006435
    Kang, J. S., Moon, Y.-S., Lee, S. H., & Park, I.-K. (2013). Inhibition of acetylcholinesterase and glutathione S-transferase of the pinewood nematode (Bursaphelenchus xylophilus) by aliphatic compounds. Pesticide Biochemistry and Physiology, 105(3), 184–188. https://doi.org/10.1016/j.pestbp.2013.02.001
    Kang, J. S., Moon, Y. S., & Lee, S. H. (2012). Inhibition properties of three acetylcholinesterases of the pinewood nematode Bursaphelenchus xylophilus by organophosphates and carbamates. Pesticide Biochemistry and Physiology, 104(2), 157–162. https://doi.org/10.1016/j.pestbp.2012.06.002
    Kang, J. S., Koh, Y. H., Moon, Y. S., & Lee, S. H. (2012). Molecular properties of a venom allergen-like protein suggest a parasitic function in the pinewood nematode Bursaphelenchus xylophilus. International Journal for Parasitology, 42(1), 63–70. https://doi.org/10.1016/j.ijpara.2011.10.006

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