Tumor Tissue Homogenizer & Homogenization Protocol

Ideal for Tumor/Cancer Tissue Homogenization

Do you spend lots of time and effort homogenizing tumor/cancer tissue samples? The Bullet Blender® tissue homogenizer delivers high quality and superior yields. No other homogenizer comes close to delivering the Bullet Blender’s winning combination of top-quality performance and budget-friendly affordability. See below for a tumor/cancer tissue homogenization protocol.

Save Time, Effort and Get Superior Results with

The Bullet Blender Homogenizer

Consistent and High Yield Results

Run up to 24 samples at the same time under microprocessor-controlled conditions, ensuring experimental reproducibility and high yield. Process samples from 10mg or less up to 3.5g.

No Cross Contamination

No part of the Bullet Blender ever touches the tissue – the sample tubes are kept closed during homogenization. There are no probes to clean between samples.

Samples Stay Cool

The Bullet Blenders’ innovative and elegant design provides convective cooling of the samples, so they do not heat up more than several degrees. In fact, our Gold+ models hold the sample temperature to about 4ºC.

Easy and Convenient to Use

Just place beads and buffer along with your tissue sample in standard tubes, load tubes directly in the Bullet Blender, select time and speed, and press start.

Risk Free Purchase

Thousands of peer-reviewed journal articles attest to the consistency and quality of the Bullet Blender homogenizer. We offer a 2 year warranty, extendable to 4 years, because our Bullet Blenders are reliable and last for many years.  

Tumor/Cancer Tissue Homogenization Protocol

Sample size

See the Protocol
microcentrifuge tube model (up to 300 mg) Small tumor/cancer samples
5mL tube model (100mg - 1g) Medium tumor/cancer samples

What Else Can You Homogenize? Tough or Soft, No Problem! 

The Bullet Blender can process a wide range of samples including organ tissue, cell culture, plant tissue, and small organisms. You can homogenize samples as tough as mouse femur or for gentle applications such as tissue dissociation or organelle isolation.

the Bullet Blender high-throughput tissue homogenizer

Want more guidance? Need a quote? Contact us:



    Bullet Blender Models

    Select Publications using the Bullet Blender to Homogenize Tumor/Cancer Tissue

    See all of our Bullet Blender publications!

    Masterson, L., Winder, D. M., Ball, S. L. R., Vaughan, K., Lehmann, M., Scholtz, L.-U., Sterling, J. C., Sudhoff, H. H., & Goon, P. K. C. (2016). Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis. BMC Cancer, 16, 367. https://doi.org/10.1186/s12885-016-2398-7
    Ruhaak, L. R., Taylor, S. L., Stroble, C., Nguyen, U. T., Parker, E. A., Song, T., Lebrilla, C. B., Rom, W. N., Pass, H., Kim, K., Kelly, K., & Miyamoto, S. (2015). Differential N-Glycosylation Patterns in Lung Adenocarcinoma Tissue. Journal of Proteome Research, 14(11), 4538–4549. https://doi.org/10.1021/acs.jproteome.5b00255
    Byun, S., Shin, S. H., Lee, E., Lee, J., Lee, S.-Y., Farrand, L., Jung, S. K., Cho, Y.-Y., Um, S.-J., Sin, H.-S., Kwon, Y.-J., Zhang, C., Tsang, B. K., Bode, A. M., Lee, H. J., Lee, K. W., & Dong, Z. (2015). The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1. Carcinogenesis, bgv148. https://doi.org/10.1093/carcin/bgv148
    Marien, E., Meister, M., Muley, T., Fieuws, S., Bordel, S., Derua, R., Spraggins, J., Van de Plas, R., Dehairs, J., Wouters, J., Bagadi, M., Dienemann, H., Thomas, M., Schnabel, P. A., Caprioli, R. M., Waelkens, E., & Swinnen, J. V. (2015). Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles: Altered Phospholipid Profiles in NSCLC. International Journal of Cancer, 137(7), 1539–1548. https://doi.org/10.1002/ijc.29517
    Jallouk, A. P., Palekar, R. U., Marsh, J. N., Pan, H., Pham, C. T. N., Schlesinger, P. H., & Wickline, S. A. (2015). Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles. Bioconjugate Chemistry, 26(8), 1640–1650. https://doi.org/10.1021/acs.bioconjchem.5b00246
    Keung, E. Z., Akdemir, K. C., Al Sannaa, G. A., Garnett, J., Lev, D., Torres, K. E., Lazar, A. J., Rai, K., & Chin, L. (2015). Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma. Journal of Clinical Investigation, 125(8), 2965–2978. https://doi.org/10.1172/JCI77976
    Danan-Gotthold, M., Golan-Gerstl, R., Eisenberg, E., Meir, K., Karni, R., & Levanon, E. Y. (2015). Identification of recurrent regulated alternative splicing events across human solid tumors. Nucleic Acids Research, 43(10), 5130–5144. https://doi.org/10.1093/nar/gkv210
    Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M.-A., Quist, M. J., Davis, L. E., Huang, E. C., Woo, P. J., Ponnuswami, A., Chen, S., Johung, T. B., Sun, W., Kogiso, M., Du, Y., Qi, L., Huang, Y., Hütt-Cabezas, M., … Monje, M. (2015). Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nature Medicine, 21(6), 555–559. https://doi.org/10.1038/nm.3855
    Dao, V., Pandeswara, S., Liu, Y., Hurez, V., Dodds, S., Callaway, D., Liu, A., Hasty, P., Sharp, Z. D., & Curiel, T. J. (2015). Prevention of Carcinogen and Inflammation-Induced Dermal Cancer by Oral Rapamycin Includes Reducing Genetic Damage. Cancer Prevention Research, 8(5), 400–409. https://doi.org/10.1158/1940-6207.CAPR-14-0313-T
    Adelaiye, R., Ciamporcero, E., Miles, K. M., Sotomayor, P., Bard, J., Tsompana, M., Conroy, D., Shen, L., Ramakrishnan, S., Ku, S.-Y., Orillion, A., Prey, J., Fetterly, G., Buck, M., Chintala, S., Bjarnason, G. A., & Pili, R. (2015). Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic Modifications. Molecular Cancer Therapeutics, 14(2), 513–522. https://doi.org/10.1158/1535-7163.MCT-14-0208
    Allensworth, J. L., Evans, M. K., Bertucci, F., Aldrich, A. J., Festa, R. A., Finetti, P., Ueno, N. T., Safi, R., McDonnell, D. P., Thiele, D. J., Van Laere, S., & Devi, G. R. (2015). Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Molecular Oncology, 9(6), 1155–1168. https://doi.org/10.1016/j.molonc.2015.02.007
    Pilon, J. L., Clausen, D. J., Hansen, R. J., Lunghofer, P. J., Charles, B., Rose, B. J., Thamm, D. H., Gustafson, D. L., Bradner, J. E., & Williams, R. M. (2015). Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere. Cancer Chemotherapy and Pharmacology, 75(4), 671–682. https://doi.org/10.1007/s00280-015-2675-1
    Awasthi, N., Hinz, S., Brekken, R. A., Schwarz, M. A., & Schwarz, R. E. (2015). Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer. Cancer Letters, 358(1), 59–66. https://doi.org/10.1016/j.canlet.2014.12.027
    Yoshida, Y., Ozawa, T., Yao, T.-W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S.-Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T., & James, C. D. (2014). NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification. Molecular Cancer Therapeutics, 13(12), 2919–2929. https://doi.org/10.1158/1535-7163.MCT-14-0306
    Ramos, P., Karnezis, A. N., Craig, D. W., Sekulic, A., Russell, M. L., Hendricks, W. P. D., Corneveaux, J. J., Barrett, M. T., Shumansky, K., Yang, Y., Shah, S. P., Prentice, L. M., Marra, M. A., Kiefer, J., Zismann, V. L., McEachron, T. A., Salhia, B., Prat, J., D’Angelo, E., … Trent, J. M. (2014). Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nature Genetics, 46(5), 427–429. https://doi.org/10.1038/ng.2928
    Valentino, J. D., Li, J., Zaytseva, Y. Y., Mustain, W. C., Elliott, V. A., Kim, J. T., Harris, J. W., Campbell, K., Weiss, H., Wang, C., Song, J., Anthony, L., Townsend, C. M., & Evers, B. M. (2014). Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors. Clinical Cancer Research, 20(5), 1212–1222. https://doi.org/10.1158/1078-0432.CCR-13-1897
    Liang, W. S., Aldrich, J., Tembe, W., Kurdoglu, A., Cherni, I., Phillips, L., Reiman, R., Baker, A., Weiss, G. J., Carpten, J. D., & Craig, D. W. (2014). Long insert whole genome sequencing for copy number variant and translocation detection. Nucleic Acids Research, 42(2), e8–e8. https://doi.org/10.1093/nar/gkt865
    Makowski, L., Zhou, C., Zhong, Y., Kuan, P. F., Fan, C., Sampey, B. P., Difurio, M., & Bae-Jump, V. L. (2014). Obesity increases tumor aggressiveness in a genetically engineered mouse model of serous ovarian cancer. Gynecologic Oncology, 133(1), 90–97. https://doi.org/10.1016/j.ygyno.2013.12.026
    Shanmugam, V., Ramanathan, R. K., Lavender, N. A., Sinari, S., Chadha, M., Liang, W. S., Kurdoglu, A., Izatt, T., Christoforides, A., Benson, H., Phillips, L., Baker, A., Murray, C., Hostetter, G., Von Hoff, D. D., Craig, D. W., & Carpten, J. D. (2014). Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. BMC Medical Genomics, 7(1), 36. https://doi.org/10.1186/1755-8794-7-36
    Naba, A., Clauser, K. R., Whittaker, C. A., Carr, S. A., Tanabe, K. K., & Hynes, R. O. (2014). Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer, 14(1), 518. https://doi.org/10.1186/1471-2407-14-518
    León-Cabrera, S., Callejas, B. E., Ledesma-Soto, Y., Coronel, J., Pérez-Plasencia, C., Gutiérrez-Cirlos, E. B., Ávila-Moreno, F., Rodríguez-Sosa, M., Hernández-Pando, R., Marquina-Castillo, B., Chirino, Y. I., & Terrazas, L. I. (2014). Extraintestinal Helminth Infection Reduces the Development of Colitis-Associated Tumorigenesis. International Journal of Biological Sciences, 10(9), 948–956. https://doi.org/10.7150/ijbs.9033
    Goh, J., Tsai, J., Bammler, T. K., Farin, F. M., Endicott, E., & Ladiges, W. C. (2013). Exercise Training in Transgenic Mice Is Associated with Attenuation of Early Breast Cancer Growth in a Dose-Dependent Manner. PLoS ONE, 8(11), e80123. https://doi.org/10.1371/journal.pone.0080123
    Travica, S., Pors, K., Loadman, P. M., Shnyder, S. D., Johansson, I., Alandas, M. N., Sheldrake, H. M., Mkrtchian, S., Patterson, L. H., & Ingelman-Sundberg, M. (2013). Colon Cancer-Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins. Clinical Cancer Research, 19(11), 2952–2961. https://doi.org/10.1158/1078-0432.CCR-13-0238
    Scrimieri, F., Askew, D., Corn, D. J., Eid, S., Bobanga, I. D., Bjelac, J. A., Tsao, M. L., Allen, F., Othman, Y. S., Wang, S.-C. G., & Huang, A. Y. (2013). Murine leukemia virus envelope gp70 is a shared biomarker for the high-sensitivity quantification of murine tumor burden. OncoImmunology, 2(11), e26889. https://doi.org/10.4161/onci.26889
    Nagarkar, D. R., Poposki, J. A., Tan, B. K., Comeau, M. R., Peters, A. T., Hulse, K. E., Suh, L. A., Norton, J., Harris, K. E., Grammer, L. C., Chandra, R. K., Conley, D. B., Kern, R. C., Schleimer, R. P., & Kato, A. (2013). Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 132(3), 593-600.e12. https://doi.org/10.1016/j.jaci.2013.04.005
    Ke, H., Augustine, C. K., Gandham, V. D., Jin, J. Y., Tyler, D. S., Akiyama, S. K., Hall, R. P., & Zhang, J. Y. (2013). CYLD Inhibits Melanoma Growth and Progression through Suppression of the JNK/AP-1 and β1-Integrin Signaling Pathways. Journal of Investigative Dermatology, 133(1), 221–229. https://doi.org/10.1038/jid.2012.253
    Gilbreath, J. J., Semino-Mora, C., Friedline, C. J., Liu, H., Bodi, K. L., McAvoy, T. J., Francis, J., Nieroda, C., Sardi, A., Dubois, A., Lazinski, D. W., Camilli, A., Testerman, T. L., & Merrell, D. (2013). A core microbiome associated with the peritoneal tumors of pseudomyxoma peritonei. Orphanet Journal of Rare Diseases, 8(1), 105. https://doi.org/10.1186/1750-1172-8-105
    Liang, W. S., Craig, D. W., Carpten, J., Borad, M. J., Demeure, M. J., Weiss, G. J., Izatt, T., Sinari, S., Christoforides, A., Aldrich, J., Kurdoglu, A., Barrett, M., Phillips, L., Benson, H., Tembe, W., Braggio, E., Kiefer, J. A., Legendre, C., Posner, R., … Von Hoff, D. (2012). Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing. PLoS ONE, 7(10), e43192. https://doi.org/10.1371/journal.pone.0043192
    Sahu, R. P., Turner, M. J., DaSilva, S. C., Rashid, B. M., Ocana, J. A., Perkins, S. M., Konger, R. L., Touloukian, C. E., Kaplan, M. H., & Travers, J. B. (2012). The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis, 33(7), 1360–1367. https://doi.org/10.1093/carcin/bgs152
    Weiss, G. J., Liang, W. S., Izatt, T., Arora, S., Cherni, I., Raju, R. N., Hostetter, G., Kurdoglu, A., Christoforides, A., Sinari, S., Baker, A. S., Metpally, R., Tembe, W. D., Phillips, L., Von Hoff, D. D., Craig, D. W., & Carpten, J. D. (2012). Paired Tumor and Normal Whole Genome Sequencing of Metastatic Olfactory Neuroblastoma. PLoS ONE, 7(5), e37029. https://doi.org/10.1371/journal.pone.0037029
    Poulikakos, P. I., Persaud, Y., Janakiraman, M., Kong, X., Ng, C., Moriceau, G., Shi, H., Atefi, M., Titz, B., Gabay, M. T., Salton, M., Dahlman, K. B., Tadi, M., Wargo, J. A., Flaherty, K. T., Kelley, M. C., Misteli, T., Chapman, P. B., Sosman, J. A., … Solit, D. B. (2011). RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature, 480(7377), 387–390. https://doi.org/10.1038/nature10662
    Winder, D. M., Ball, S. L., Vaughan, K., Hanna, N., Woo, Y., Fränzer, J.-T., Sterling, J. C., Stanley, M. A., Sudhoff, H., & Goon, P. K. (2009). Sensitive HPV detection in oropharyngeal cancers. BMC Cancer, 9(1), 440. https://doi.org/10.1186/1471-2407-9-440

    Have any questions? Ask us!

    Contact Our Sales Team
    Success!

    The discount has been applied. You will see it when you checkout.

    There has been a problem

    Unfortunately this discount cannot be applied to your cart.